Great post, particularly on the protective effect of the flu vaccine for cardiovascular outcomes, which I didn't know about.
But...given the p value of the large RCT (https://pubmed.ncbi.nlm.nih.gov/34459211/) is 0.04 and the upper limit of the confidence interval is a hair's breadth from the line of no effect, does this need further replication before taken as gospel?
I note this trial was in a population who weren't that elderly (mean age 60) but who did have a recent MI which presumably needs to be taken into consideration when extrapolating?
Great post, particularly on the protective effect of the flu vaccine for cardiovascular outcomes, which I didn't know about.
But...given the p value of the large RCT (https://pubmed.ncbi.nlm.nih.gov/34459211/) is 0.04 and the upper limit of the confidence interval is a hair's breadth from the line of no effect, does this need further replication before taken as gospel?
I note this trial was in a population who weren't that elderly (mean age 60) but who did have a recent MI which presumably needs to be taken into consideration when extrapolating?
Would be interested to hear your thoughts!
I wish someone would give you and Stuart like $10 million to found a new science magazine.
How common is asymptomatic flu?